Sodium Methoxide → 2-Bromo-6-methoxypyridin-3-ol

HRID 1846236ノート

反応式

HRID 1846236 の反応式
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[CH3:10][O-:11].[Na+]>CN(C=O)C>[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:10])[N:3]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 467386822-Bromo-6-chloropyridin-3-ol

生成物 1

HCID 899642662-Bromo-6-methoxypyridin-3-ol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a 0° C. solution of 2-bromo-6-chloropyridin-3-ol (1 eq.) and DMF (0.2 M) is added NaOMe (2.2 eq.). The solution is allowed to warm to room temperature as the cooling bath expires and allowed to stir at room temperature for 24 h. The reaction is quenched with saturated NH4Cl and diluted with water. The aqueous solution is extracted with EtOAc. The combined EtOAc layers are dried over MgSO4, concentrated in vacuo, and purified by column chromatography to give the title compound.

後処理

  1. customThe reaction is quenched with saturated NH4Cl
  2. additiondiluted with water
  3. extractionThe aqueous solution is extracted with EtOAc
  4. dry with materialThe combined EtOAc layers are dried over MgSO4
  5. concentrationconcentrated in vacuo
  6. custompurified by column chromatography

出典と根拠

ORDレコード
ord-da3795bddaca487fa6f4a27f388fbeab
出典データセット
uspto-grants-2015_02
特許番号
US08952009B2

反応ノート

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