Azidotrimethylsilane → [[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(1H-indol-5-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine

HRID 18463

反応式

HRID 18463 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[NH:10]1[C:18]2[C:13](=[CH:14][C:15]([CH:19]=O)=[CH:16][CH:17]=2)[CH:12]=[CH:11]1.C[Si]([N:25]=[N+:26]=[N-:27])(C)C.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N+:36]#[C-:37])=[CH:31][CH:30]=1>CO>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][N:36]2[C:37]([CH:19]([NH:9][CH2:8][CH2:7][CH2:6][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)[C:15]3[CH:14]=[C:13]4[C:18](=[CH:17][CH:16]=3)[NH:10][CH:11]=[CH:12]4)=[N:27][N:26]=[N:25]2)=[CH:31][CH:30]=1

参加物

6

反応物 4

HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 589040Indole-5-carboxaldehydeHCID 27574091-Chloro-4-(isocyanomethyl)benzene

生成物 1

HCID 59345367[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(1H-indol-5-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and 1H-Indole-5-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-f940c1933ff04e1d9ae29bae6ac77221
出典データセット
uspto-grants-2010_06
特許番号
US07741354B2

関連ノート

読み込み中…