Water → 6-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

HRID 1846418ノート

反応式

HRID 1846418 の反応式
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1.O>CN(C=O)C>[Cl:19][C:20]1[N:21]=[CH:22][N:23]=[C:24]([O:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:25]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669780936-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one

生成物 1

HCID 866638916-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.10 g (0.60 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF were combined with 0.10 g (0.70 mmol) potassium carbonate and stirred for 15 min at RT. Then 0.10 g (0.60 mmol) 4,6-dichloropyrimidine were added to the reaction mixture and stirred overnight at RT. Then water was added and the precipitate formed was suction filtered, washed and dried i. vac.

後処理

  1. stirringstirred overnight at RT
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried i

出典と根拠

ORDレコード
ord-07131b398064435881a0d3a6fe1e5e0c
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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