4,6-Dichloropyrimidine → 6-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

HRID 1846428ノート

反応式

HRID 1846428 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[Cl:13][C:14]1[CH:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=1>C(O)CCC>[Cl:13][C:14]1[N:15]=[CH:16][N:17]=[C:18]([NH:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:19]=1

参加物

4

反応物 2

HCID 709434,6-DichloropyrimidineHCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

生成物 1

HCID 866638946-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

400 mg (2.40 mmol) 6-amino-4-methyl-3H-benzoxazol-2-one, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.10 mL (8.00 mmol) TEA in 5 mL 1-butanol were stirred for 1 h at 100° C. After cooling to RT the reaction mixture was evaporated down and the residue was washed with water and saturated sodium hydrogen carbonate solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

後処理

  1. customwas evaporated down
  2. washthe residue was washed with water and saturated sodium hydrogen carbonate solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

出典と根拠

ORDレコード
ord-ea34a53c021d48cf9ce0601b0b40583a
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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