4,6-Diiodopyrimidine → (6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

HRID 1846440ノート

反応式

HRID 1846440 の反応式
Cl.[CH3:2][N:3]1[C:7]2[C:8]([CH3:13])=[CH:9][C:10]([NH2:12])=[CH:11][C:6]=2[N:5]=[C:4]1[CH3:14].[I:15][C:16]1[CH:21]=[C:20](I)[N:19]=[CH:18][N:17]=1>C(O)CCC>[I:15][C:16]1[N:17]=[CH:18][N:19]=[C:20]([NH:12][C:10]2[CH:9]=[C:8]([CH3:13])[C:7]3[N:3]([CH3:2])[C:4]([CH3:14])=[N:5][C:6]=3[CH:11]=2)[CH:21]=1

参加物

4

反応物 2

HCID 157602954,6-DiiodopyrimidineHCID 669781471,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride

生成物 1

HCID 86663900(6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

150 mg (0.700 mmol) 1,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride, 260 mg (0.800 mmol) 4,6-diiodopyrimidine, 0.300 mL (2.00 mmol) TEA and 5.0 mL 1-butanol were combined and stirred for 1 h at RT. The reaction mixture was evaporated down and the residue was extracted with DCM and 1N aqueous sodium hydroxide solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

後処理

  1. customThe reaction mixture was evaporated down
  2. extractionthe residue was extracted with DCM and 1N aqueous sodium hydroxide solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

出典と根拠

ORDレコード
ord-bfcbd8a1236646ef9474dec19935d0ea
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

読み込み中…