Water → HCID 86663906、化合物

HRID 1846448ノート

反応式

HRID 1846448 の反応式
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]1[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([CH3:15])[N:9]=1.[OH:16][C:17]1[CH:26]=[C:25]([CH3:27])[C:20]2[NH:21][C:22](=[O:24])[O:23][C:19]=2[CH:18]=1.O>CN(C=O)C>[Cl:14][C:12]1[N:11]=[C:10]([CH3:15])[N:9]=[C:8]([O:16][C:17]2[CH:26]=[C:25]([CH3:27])[C:20]3[NH:21][C:22](=[O:24])[O:23][C:19]=3[CH:18]=2)[CH:13]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2349974,6-Dichloro-2-methylpyrimidineHCID 669780936-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one

生成物 1

HCID 86663906HCID 86663906、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

100 mg (0.724 mmol) potassium carbonate and 110 mg (0.655 mmol) 4,6-dichloro-2-methyl-pyrimidine were added to 100 mg (0.575 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF and the mixture was stirred for 2 h at RT. Then 15 mL water were added and the mixture was stirred overnight at RT. The precipitate formed was suction filtered, washed with water and dried i. vac.

後処理

  1. stirringthe mixture was stirred overnight at RT
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried i

出典と根拠

ORDレコード
ord-f9a7d0a08fda4b09b0e8818a014a419b
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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