4-Acetylamino-3-methyl-5-nitro-phenyl acetate → 4-Amino-3-methyl-5-nitrophenol

HRID 1846451ノート

反応式

HRID 1846451 の反応式
C([O:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([NH:14]C(=O)C)=[C:7]([CH3:18])[CH:6]=1)(=O)C>Cl>[NH2:14][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]([OH:4])=[CH:6][C:7]=1[CH3:18]

参加物

3

反応物 1

HCID 669782344-Acetylamino-3-methyl-5-nitro-phenyl acetate

生成物 1

HCID 669782964-Amino-3-methyl-5-nitrophenol

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

20.4 g (80.7 mmol) 4-acetylamino-3-methyl-5-nitro-phenyl acetate in 100 mL semi-concentrated aqueous hydrochloric acid were refluxed for 2 h. Then the reaction mixture was evaporated down, the residue was triturated with acetone and suction filtered. After washing with acetone and diethyl ether the precipitate was dried under HV. The mother liquor was evaporated down, the residue was taken up in water and freeze-dried.

後処理

  1. customThen the reaction mixture was evaporated down
  2. customthe residue was triturated with acetone and suction
  3. filtrationfiltered
  4. washAfter washing with acetone and diethyl ether the precipitate
  5. customwas dried under HV
  6. customThe mother liquor was evaporated down
  7. customfreeze-dried

出典と根拠

ORDレコード
ord-1537f24eb5eb4816a570794d73224cec
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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