p-Toluenesulfonic acid monohydrate → HCID 178516181、化合物
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]([CH:13]1[CH2:17][CH2:16][O:15][CH2:14]1)=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:9][C:4]1[C:3]2[NH:10][C:11]([CH:13]3[CH2:17][CH2:16][O:15][CH2:14]3)=[N:1][C:2]=2[CH:7]=[C:6]([OH:8])[CH:5]=1参加物
4
実験手順
0.10 g (0.39 mmol) N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydrofuran-3-carboxamide were placed in 20 mL methanol, a spatula tip of p-toluenesulphonic acid monohydrate was added and the mixture was boiled for 2 h. The reaction mixture was evaporated down i.vac. and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.
後処理
- customThe reaction mixture was evaporated down i.vac
- customand purified by chromatography
- additionThe fractions containing product
- customevaporated down i.vac
出典と根拠
- ORDレコード
- ord-d47bc832bb53472b83595fbb6a198255
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952014B2
反応ノート
読み込み中…