Potassium Carbonate → HCID 178478257、化合物
反応式
[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([OH:16])[CH:3]=1.[Cl:17][C:18]1[CH:23]=[C:22](Cl)[N:21]=[CH:20][N:19]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([O:16][C:22]2[CH:23]=[C:18]([Cl:17])[N:19]=[CH:20][N:21]=2)[CH:3]=1参加物
5
実験手順
80 mg (0.34 mmol) 7-chloro-2-(tetrahydrofuran-3-yl)-1H-benzo[d]imidazol-5-ol and 51 mg (0.34 mmol) 4,6-dichloropyrimidine were placed in 2.0 mL DMF. 55 mg (0.40 mmol) potassium carbonate were added and the mixture was stirred overnight at RT. The reaction mixture was filtered and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.