Acrolein dimer → {(3,4-Dihydro-2H-pyran-2-yl)-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-yl]-methyl}-(3-imidazol-1-yl-propyl)-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Acrolein dimer	HCID 60994	—
反応物	Azidotrimethylsilane	HCID 78378	—
反応物	1H-Imidazole-1-propanamine	HCID 78736	—
反応物	2-Isocyano-N,N-dimethylethanamine	HCID 2771550	—
溶媒	Methanol	HCID 887	—
生成物	{(3,4-Dihydro-2H-pyran-2-yl)-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-yl]-methyl}-(3-imidazol-1-yl-propyl)-amine	HCID 25059390	—

反応手順

3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and (2-Isocyano-ethyl)-dimethyl-amine (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07741354B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-859a5691f5d641a8b6aba2247b719733
出典メモ	uspto-grants-2010_06