Water → 6-(6-chloro-2-trifluoromethyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

HRID 1846509ノート

反応式

HRID 1846509 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=1.[OH:13][C:14]1[CH:23]=[CH:22][C:17]2[NH:18][C:19](=[O:21])[O:20][C:16]=2[CH:15]=1.[C:24](=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[Cl:8][C:6]1[N:5]=[C:4]([C:9]([F:12])([F:11])[F:10])[N:3]=[C:2]([O:13][C:14]2[CH:23]=[C:22]([CH3:24])[C:17]3[NH:18][C:19](=[O:21])[O:20][C:16]=3[CH:15]=2)[CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 1571672(3H)-Benzoxazolone, 6-hydroxy-HCID 157131974,6-Dichloro-2-trifluoromethylpyrimidine

生成物 1

HCID 866639286-(6-chloro-2-trifluoromethyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.40 g (1.86 mmol) 4,6-dichloro-2-trifluoromethylpyrimidine, 0.31 g (1.88 mmol) 6-hydroxy-2-benzoxazolinone and 0.28.g (2.03 mmol) potassium carbonate in 2.0 mL DMF were stirred for 2 h at RT. The reaction mixture was mixed with water and stirred for 1 h at RT. The precipitate formed was suction filtered, washed and dried.

後処理

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried

出典と根拠

ORDレコード
ord-92379cd1e89f434898de727d40406b40
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

読み込み中…