Pyridinium chloride → 2-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

HRID 1846515ノート

反応式

HRID 1846515 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([C:13]([F:16])([F:15])[F:14])[C:6]2[N:10]=[C:9]([CH3:11])[NH:8][C:7]=2[CH:12]=1.Cl.N1C=CC=CC=1>CN(C=O)C>[CH3:11][C:9]1[NH:8][C:7]2[CH:12]=[C:3]([OH:2])[CH:4]=[C:5]([C:13]([F:16])([F:14])[F:15])[C:6]=2[N:10]=1

参加物

4

反応物 2

HCID 10176127Pyridinium chlorideHCID 669782136-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole

生成物 1

HCID 669782592-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A well stirred mixture of 450 mg (1.95 mmol) 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole and 2.50 g (21.6 mmol) pyridine hydrochloride was heated for 15 min to 200° C. After cooling to RT the reaction mixture was combined with 3.0 mL DMF and purified by preparative HPLC. The fractions containing product were combined and evaporated down i.vac.

後処理

  1. temperaturewas heated for 15 min to 200° C
  2. custompurified by preparative HPLC
  3. additionThe fractions containing product
  4. customevaporated down i.vac

出典と根拠

ORDレコード
ord-68c0fe24adfa46c5894f204c1205570c
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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