Potassium Carbonate → 6-(6-chloro-pyrimidin-4-yloxy)-2-methyl-4-trifluoromethyl-1H-benzimidazole

HRID 1846516ノート

反応式

HRID 1846516 の反応式
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]1[CH:13]=[C:12]([Cl:14])[N:11]=[CH:10][N:9]=1.[CH3:15][C:16]1[NH:17][C:18]2[CH:24]=[C:23]([OH:25])[CH:22]=[C:21]([C:26]([F:29])([F:28])[F:27])[C:19]=2[N:20]=1>CN(C=O)C>[Cl:14][C:12]1[N:11]=[CH:10][N:9]=[C:8]([O:25][C:23]2[CH:22]=[C:21]([C:26]([F:29])([F:28])[F:27])[C:19]3[N:20]=[C:16]([CH3:15])[NH:17][C:18]=3[CH:24]=2)[CH:13]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669782592-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

生成物 1

HCID 866639306-(6-chloro-pyrimidin-4-yloxy)-2-methyl-4-trifluoromethyl-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

221 mg (1.60 mmol) potassium carbonate were added at RT to 245 mg (1.60 mmol) 4,6-dichloropyrimidine and 330 mg (1.52 mmol) 2-methyl-7-trifluoromethyl-3H-benzimidazole-5-ol in 5.0 mL DMF and the mixture was stirred overnight at RT. The reaction mixture was poured onto water. The precipitate formed was filtered off, washed with water and dried.

後処理

  1. additionThe reaction mixture was poured onto water
  2. customThe precipitate formed
  3. filtrationwas filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-5c5c21a408ae447dad8cdcab8db44074
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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