Benzaldehyde, 2-hydroxy-5-methyl- → 2-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

HRID 18466

反応式

HRID 18466 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH:13]=O.C[Si]([N:24]=[N+:25]=[N-:26])(C)C.[N+:27]([CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])#[C-:28]>CO>[CH3:31][C:30]([CH3:33])([CH3:32])[CH2:29][N:27]1[C:28]([CH:13]([NH:9][CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:12]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=2[OH:10])=[N:26][N:25]=[N:24]1

参加物

6

反応物 4

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 27586461-Isocyano-2,2-dimethyl-propane

生成物 1

HCID 593454072-[[1-(2,2-Dimethyl-propyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Isocyano-2,2-dimethyl-propane (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-cfceddfb4bc9409090c9ad66df42eb23
出典データセット
uspto-grants-2010_06
特許番号
US07741354B2

関連ノート

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