Hydrochloride methanol → 3-(3-Chloro-pyrazin-2-yloxy)-cyclobutylamine hydrochloride
反応式
[Cl:1][C:2]1[C:3]([O:8][CH:9]2[CH2:12][CH:11]([NH:13]C(=O)OC(C)(C)C)[CH2:10]2)=[N:4][CH:5]=[CH:6][N:7]=1.Cl.CO>CO>[ClH:1].[Cl:1][C:2]1[C:3]([O:8][CH:9]2[CH2:10][CH:11]([NH2:13])[CH2:12]2)=[N:4][CH:5]=[CH:6][N:7]=1参加物
4
実験手順
To a mixture of tert-butyl (3-((3-chloropyrazin-2-yl)oxy)cyclobutyl)carbamate (2.8 g, 9.61 mmol) in MeOH (20 mL) was added HCl/MeOH (20 mL, saturated with HCl gas), and then stirred at RT for 1 hour. The reaction mixture was concentrated to give 3-((3-chloropyrazin-2-yl)oxy)cyclobutanamine hydrochloride (2.2 g, 9.61 mmol, 100%). ESI-MS (M+1): 200 calc. for C8H10ClN3O 199.
後処理
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-4e781e98112a4fd18c3507a081e8e31d
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952037B2
反応ノート
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