Benzaldehyde, 2-hydroxy-5-methyl- → 2-[(1-Cyclopropyl-1H-tetrazol-5-yl)-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

HRID 18468

反応式

HRID 18468 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH:13]=O.C[Si]([N:24]=[N+:25]=[N-:26])(C)C.[N+:27]([CH:29]1[CH2:31][CH2:30]1)#[C-:28]>CO>[CH:29]1([N:27]2[C:28]([CH:13]([NH:9][CH2:8][CH2:7][CH2:6][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)[C:12]3[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=3[OH:10])=[N:26][N:25]=[N:24]2)[CH2:31][CH2:30]1

参加物

6

反応物 4

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 2758008Isocyanocyclopropane

生成物 1

HCID 250606982-[(1-Cyclopropyl-1H-tetrazol-5-yl)-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and Isocyano-cyclopropane (mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-e00c3fef56994855928f8ddb1e1bebb6
出典データセット
uspto-grants-2010_06
特許番号
US07741354B2

関連ノート

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