N-(2-aminophenyl)-3-(benzyloxy)cyclobutanecarboxamide → 2-(3-(Benzyloxy)cyclobutyl)-1H-benzo[d]imidazole

HRID 1846813ノート

反応式

HRID 1846813 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([CH:11]1[CH2:14][CH:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:12]1)=O>C(O)(=O)C>[CH2:16]([O:15][CH:13]1[CH2:14][CH:11]([C:9]2[NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH2:12]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

3

反応物 1

HCID 67478928N-(2-aminophenyl)-3-(benzyloxy)cyclobutanecarboxamide

生成物 1

HCID 674813742-(3-(Benzyloxy)cyclobutyl)-1H-benzo[d]imidazole

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of N-(2-aminophenyl)-3-(benzyloxy)cyclobutanecarboxamide (1.78 g, 6.01 mmol) in acetic acid was heated to 100° C. for 1 h, then cooled to RT. The acetic acid was removed in vacuo and ethyl acetate was added to the resulting oil. The resulting suspension was filtered and the collected solid was air dried to give 2-(3-(Benzyloxy)cyclobutyl)-1H-benzo[d]imidazole. The filtrate was concentrated in vacuo to give another suspension, which was filtered, air dried, and added to the first crop of product to give a total of 0.96 g (3.43 mmol, 57% yield) of 2-(3-(Benzyloxy)cyclobutyl)-1H-benzo[d]imidazole as a white solid.

後処理

  1. customThe acetic acid was removed in vacuo and ethyl acetate
  2. additionwas added to the resulting oil
  3. filtrationThe resulting suspension was filtered
  4. customdried

出典と根拠

ORDレコード
ord-bf13e5d5f2164d6cb61b3aef6506404a
出典データセット
uspto-grants-2015_02
特許番号
US08952037B2

反応ノート

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