Methyl 2,2-Difluoro-3-methoxypropionate → N'-(5-bromopyridin-2-yl)-2,2-difluoro-3-methoxypropanehydrazide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH2:9])=[N:6][CH:7]=1.[F:10][C:11]([F:19])([CH2:16][O:17][CH3:18])[C:12](OC)=[O:13]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][NH:9][C:12](=[O:13])[C:11]([F:19])([F:10])[CH2:16][O:17][CH3:18])=[N:6][CH:7]=1参加物
4
実験手順
(5-bromo-2-hydrazinylpyridine (1.83 g, 9.73 mmol) and methyl 2,2-difluoro-3-methoxypropanoate (1.00 g, 6.49 mmol) were refluxed in toluene (35 mL) overnight. The reaction mixture was concentrated and purified by chromatography (EtOAc: hexanes=1:4) to give N′-(5-bromopyridin-2-yl)-2,2-difluoro-3-methoxypropanehydrazide.
後処理
- concentrationThe reaction mixture was concentrated
- custompurified by chromatography (EtOAc: hexanes=1:4)
出典と根拠
- ORDレコード
- ord-c40cb46ee02842af9d5f6e048c7f3b96
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952034B2
反応ノート
読み込み中…