Hydrochloric Acid → 3-(6,7-Difluoro-2-oxoquinoxalin-1(2H)-yl)propanal

反応式

[O:1]1CCO[CH:2]1[CH2:6][CH2:7][N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:19])=[C:15]([F:18])[CH:16]=2)[N:11]=[CH:10][C:9]1=[O:20].Cl.C(=O)([O-])O.[Na+]>O1CCOCC1>[F:19][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][C:15]=1[F:18])[N:8]([CH2:7][CH2:6][CH:2]=[O:1])[C:9](=[O:20])[CH:10]=[N:11]2

参加物

実験手順

To a solution of 1-[2-(1,3-dioxolan-2-yl)ethyl]-6,7-difluoroquinoxalin-2(1H)one (0.6 g, 2.1 mmol) in dioxane (10 ml) was added 4N hydrochloric acid (10 ml) and the mixture was stirred at room temperature for 4 hours. An aqueous solution of sodium hydrogen carbonate was added thereto, the mixture was extracted with ethyl acetate, and the obtained organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained crude product was dried in vacuum and used as such for the next step. 0.3 g (59%).