Hydrochloric Acid → 3-(7-Fluoro-2-oxoquinoxalin-1(2H)-yl)propanal

反応式

[O:1]1CCO[CH:2]1[CH2:6][CH2:7][N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=2)[N:11]=[CH:10][C:9]1=[O:19].Cl.C(=O)([O-])O.[Na+]>O1CCOCC1>[F:18][C:15]1[CH:16]=[C:17]2[C:12]([N:11]=[CH:10][C:9](=[O:19])[N:8]2[CH2:7][CH2:6][CH:2]=[O:1])=[CH:13][CH:14]=1

参加物

実験手順

To a solution of 1-[2-(1,3-dioxolan-2-yl)ethyl]-7-fluoroquinoxalin-2(1H)-one (0.6 g, 2.3 mmol) in 1,4-dioxane (6.8 ml) was added 4N hydrochloric acid (24 ml) and the mixture was stirred at room temperature for 5 hours. An aqueous solution of sodium hydrogen carbonate was added thereto and then the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure and dried under vacuum. 0.6 g (quantitative).