2H-Pyran-3(4H)-one, dihydro- → 3-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

HRID 18475

反応式

HRID 18475 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]3[CH2:14]N(C(OC(C)(C)C)=O)C[CH2:17][C:12]=3[NH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].[O:25]1CCCC(=O)[CH2:26]1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]3[CH2:14][CH2:26][O:25][CH2:17][C:12]=3[NH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

参加物

3

反応物 2

HCID 901092H-Pyran-3(4H)-one, dihydro-HCID 59345327tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

生成物 1

HCID 593453523-(3,4-Difluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

実験手順

Intermediate 16B was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one LCMS (+ESI) m/z=236 [M+H]+. 1H NMR (CDCl3) δ 7.37-7.41 (m, 1H), 7.29-7.32 (m, 1H) 7.17-7.24 (m, 1H), 4.76 (s, 2H), 3.95 (t, J=5.5 Hz, 2H), 2.84 (t, J=5.5 Hz, 2H).

出典と根拠

ORDレコード
ord-6e0b9274922e4fb6a2c5c20b9494402a
出典データセット
uspto-grants-2010_06
特許番号
US07741350B1

関連ノート

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