化工社化工社 化学情報印刷レポート · 研究参考用
2H-Pyran-3(4H)-one, dihydro- → 3-(2,4,5-Trifluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2H-Pyran-3(4H)-one, dihydro- | HCID 90109 | — |
| 反応物 | 2,4,5-Trifluorobenzoyl chloride | HCID 145164 | — |
| 反応物 | tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate | HCID 59345327 | — |
| 生成物 | 3-(2,4,5-Trifluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole | HCID 59345342 | — |
反応手順
Intermediate 16D was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one, and replacing 3,4-difluorobenzoyl chloride with 2,4,5-trifluorobenzoyl chloride. LCMS (+ESI) m/z=255 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741350B1 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-36dedcaa54664e099a65833376c16631 |
| 出典メモ | uspto-grants-2010_06 |