Methanol → Methyl 3-fluoro-4-nitrobenzoate
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14]O>>[CH3:14][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([F:1])[CH:3]=1参加物
3
実験手順
A 1 L round bottom flask equipped with a stir bar and reflux condenser was charged 5H2SO4 (4 mL), methanol (400 mL) and 3-fluoro-4-nitrobenzoic acid (10 g). The reaction mixture was heated at reflux temperatures with vigorous stirring for 18 h. The methanol was removed and the crude residue was triturated with hexane and concentrated to give a colorless solid (9.79 g) that was used without further purification.
後処理
- customA 1 L round bottom flask equipped with a stir bar
- temperaturereflux condenser
- temperatureThe reaction mixture was heated
- temperatureat reflux temperatures
- customThe methanol was removed
- customthe crude residue was triturated with hexane
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-536115a2a5e24beb829c5c8865d8c9cb
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741355B2
反応ノート
読み込み中…