Methanol → Methyl 3-fluoro-4-nitrobenzoate

HRID 18482

反応式

HRID 18482 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=[O:6].[CH3:14]O>>[CH3:14][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([F:1])[CH:3]=1

参加物

3

反応物 2

HCID 887MethanolHCID 2306533-Fluoro-4-nitrobenzoic acid

生成物 1

HCID 592761Methyl 3-fluoro-4-nitrobenzoate

実験手順

A 1 L round bottom flask equipped with a stir bar and reflux condenser was charged 5H2SO4 (4 mL), methanol (400 mL) and 3-fluoro-4-nitrobenzoic acid (10 g). The reaction mixture was heated at reflux temperatures with vigorous stirring for 18 h. The methanol was removed and the crude residue was triturated with hexane and concentrated to give a colorless solid (9.79 g) that was used without further purification.

後処理

  1. customA 1 L round bottom flask equipped with a stir bar
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux temperatures
  5. customThe methanol was removed
  6. customthe crude residue was triturated with hexane
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-536115a2a5e24beb829c5c8865d8c9cb
出典データセット
uspto-grants-2010_06
特許番号
US07741355B2

関連ノート

読み込み中…