Morpholine → 4-(Morpholin-4-yl)pyridin-2-amine
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CC(N(C)C)=O>[O:12]1[CH2:13][CH2:14][N:9]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=2)[CH2:10][CH2:11]1参加物
4
反応条件
- 温度
- 200 °C
実験手順
A mixture of 4-chloropyridin-2-amine (400 mg, 3.1 mmol) and morpholine (2 mL) in 2 mL of DMA was heated at 200° C. for 5 min in a microwave reactor. LCMS analysis indicated completion of the reaction. The mixture was partitioned between EtOAc and brine, and the organic layer was dried over Na2SO4 and concentrated under reduced pressure to give crude 4-morpholinopyridin-2-amine as a yellow solid (350 mg). LCMS (ESI) m/z 180 (M+H)+.
後処理
- customcompletion of the reaction
- customThe mixture was partitioned between EtOAc and brine
- dry with materialthe organic layer was dried over Na2SO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9daf0ffe0a204f6c8230df2a2f509553
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952058B2
反応ノート
読み込み中…