3-Borono-4-chlorobenzoic acid → 4-Chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid
反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([Cl:13])=[C:8](B(O)O)[CH:9]=1)([OH:3])=[O:2].Br[C:15]1[C:20]([C:21]#[N:22])=[CH:19][C:18]([C:23]([F:26])([F:25])[F:24])=[N:17][CH:16]=1>>[Cl:13][C:7]1[C:8]([C:15]2[CH:16]=[N:17][C:18]([C:23]([F:25])([F:26])[F:24])=[CH:19][C:20]=2[C:21]#[N:22])=[CH:9][C:4]([C:1]([OH:3])=[O:2])=[CH:5][CH:6]=1参加物
3
実験手順
Similarly, 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoic acid was prepared according to the above procedure from 5-carboxy-2-chloro-phenylboronic acid and 5-bromo-2-trifluoromethyl-isonicotinonitrile 1-1.
出典と根拠
- ORDレコード
- ord-87e7f4062b764a1893a159aab41d6a8e
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952161B2
反応ノート
読み込み中…