HCID 86643578、化合物 → 1-Chloro[1]benzothieno[2,3-c]pyridine

HRID 1848958ノート

反応式

HRID 1848958 の反応式
[Cl:1][C:2]1[C:7]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6](N)[CH:5]=[CH:4][N:3]=1>CC(O)=O>[Cl:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=[CH:4][N:3]=1

参加物

3

反応物 1

HCID 86643578HCID 86643578、化合物

生成物 1

HCID 8198151-Chloro[1]benzothieno[2,3-c]pyridine収率 88%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a 250 mL round flask was added 2-chloro-3-phenylthio-4-aminopyridine (2.7 g, 11.4 mmol), and 60 mL of glacial AcOH. To this clear solution, ButONO (1.36 g, 11.45 mmol) was added drop by drop. After stirring at room temperature for 1 h, another (1.36 g 11.45) mmol of ButONO was added. The mixture was continued to stir at room temperature for 18 h. The reaction was quenched by water, and the product was purified by a silica gel column. Yield (88%) of 1-chloro-benzothieno[2,3-c]pyridine was 2.2 g.

後処理

  1. additionTo this clear solution, ButONO (1.36 g, 11.45 mmol) was added drop by drop
  2. stirringto stir at room temperature for 18 h
  3. customThe reaction was quenched by water
  4. customthe product was purified by a silica gel column

出典と根拠

ORDレコード
ord-42ea29f4d52b4257b236da1d9ba6a672
出典データセット
uspto-grants-2015_02
特許番号
US08952363B2

反応ノート

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