Hydrochloric Acid → 2,6-Dimethyl-L-tyrosyl-N-[(2R)-2-amino-3-phenylpropyl]-D-alaninamide

HRID 1849990

反応式

HRID 1849990 の反応式
C(OC([NH:8][C@H:9]([C:20]([NH:22][C@@H:23]([C:25]([NH:27][CH2:28][C@H:29]([NH2:37])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:26])[CH3:24])=[O:21])[CH2:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14]([OH:18])=[CH:13][C:12]=1[CH3:19])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:19][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[C:16]([CH3:17])[C:11]=1[CH2:10][C@@H:9]([C:20]([NH:22][C@@H:23]([C:25]([NH:27][CH2:28][C@H:29]([NH2:37])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:26])[CH3:24])=[O:21])[NH2:8]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 71229909N-(tert-Butoxycarbonyl)-2,6-dimethyl-L-tyrosyl-N-{(2R)-2-amino-3-phenylpropyl}-D-alaninamide

生成物 1

HCID 712299072,6-Dimethyl-L-tyrosyl-N-[(2R)-2-amino-3-phenylpropyl]-D-alaninamide収率 56%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

N-(tert-Butoxycarbonyl)-2,6-dimethyl-L-tyrosyl-N-{(2R)-2-amino-3-phenylpropyl}-D-alaninamide (203 mg, 0.36 mmol) was dissolved in 1 mL dioxane and hydrogen chloride (4M solution in dioxane, 1 mL, 4 mmol) added and the mixture stirred at room temperature for 16 h. The mixture was evaporated under reduced pressure and the residue purified by preparative HPLC and then freeze dried to provide the title compound (83 mg, 56%) as a white solid.

後処理

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue purified by preparative HPLC
  3. customfreeze dried

出典と根拠

ORDレコード
ord-aa6ae07089374649a4b4dce49aee91cf
出典データセット
uspto-grants-2015_02
特許番号
US08957025B2

関連ノート

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