Hydrochloric Acid → HCID 67469068、化合物

HRID 1850239ノート

反応式

HRID 1850239 の反応式
[Br:1][C:2]1[C:3]([CH:8]2[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[ClH:19]>CO>[ClH:19].[NH:10]1[CH2:9][CH:8]([C:3]2[C:2]([Br:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 58546913HCID 58546913、化合物

生成物 1

HCID 67469068HCID 67469068、化合物収率 108.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl 3-(3-bromopyridin-2-yl)azetidine-1-carboxylate (3) (266 g, 0.849 mol, 1 eq.) in methanol (6 L) was added concentrated HCl (350 mL, 4.2 mol, 4.95 eq.) and the resulting mixture was stirred at RT for 92 hrs. The mixture was concentrated and dried using a rotavapor to obtain 230 g of 2-(azetidin-3-yl)-3-bromopyridine hydrochloride (4).

後処理

  1. concentrationThe mixture was concentrated
  2. customdried

出典と根拠

ORDレコード
ord-e5017e7ff5b94ccf90111d6ad71d8222
出典データセット
uspto-grants-2015_02
特許番号
US08957073B2

反応ノート

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