Hydrochloride methanol → HCID 67469208、化合物

反応式

C(OC([N:8]1[CH2:11][CH:10]([C:12]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24].CO>>[ClH:24].[NH:8]1[CH2:9][CH:10]([C:12]2[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:11]1

参加物

反応物 2

HCID 21893726Hydrochloride methanol

HCID 58547347HCID 58547347、化合物

生成物 1

HCID 67469208HCID 67469208、化合物収率 100%

実験手順

A mixture of 3-(3-phenyl-pyridin-2-yl)-azetidine-1-carboxylic acid tert-butyl ester (79) (130 mg, 0.60 mmol) in HCl/MeOH solution (5 mL) was stirred at RT for 30 min. Then the solvent was evaporated at 40° C. to give 2-Azetidin-3-yl-3-phenyl-pyridine hydrochloride (80) (100 mg, 100% yield) as a yellow solid.

後処理

customThen the solvent was evaporated at 40° C.

出典と根拠

ORDレコード: ord-13066d82b0b6445b95b28e1c3ad5932d
出典データセット: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08957073B2

反応ノート

読み込み中…

参加物