Hydrochloride methanol → 2-Phenyl-3-piperidin-4-YL-pyrazine hydrochloride

反応式

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26].CO>>[ClH:26].[C:20]1([C:19]2[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:15][CH:16]=[CH:17][N:18]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

参加物

反応物 2

HCID 21893726Hydrochloride methanol

HCID 585476344-(3-Phenyl-pyrazin-2-YL)-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 674680142-Phenyl-3-piperidin-4-YL-pyrazine hydrochloride収率 100%

実験手順

A mixture of 4-(3-Phenyl-pyrazin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (89) (128 mg, 0.38 mmol) in 4 M HCl/MeOH solution (10 mL) was stirred at RT. for 30 min. Then the solvent was evaporated at 40° C. to give 2-phenyl-3-piperidin-4-yl-pyrazine hydrochloride (90) (105 mg, 0.38 mmol, 100% yield) as a yellow solid.

後処理

customThen the solvent was evaporated at 40° C.

出典と根拠

ORDレコード: ord-4552f1a88f9c4045bd874a326f29c93e
出典データセット: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08957073B2

反応ノート

読み込み中…

参加物