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4-Bromo-2-chlorotoluene → 1-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-2-chlorotoluene | HCID 2735554 | — |
| 反応物 | HCID 66759981 | HCID 66759981 | — |
| 生成物 | 1-(3-Chloro-4-methylphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485015 | 58% |
反応手順
By using 1-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine hydrochloric acid salt (311 mg, 1.00 mmol) synthesized in Reference example 147 and 4-bromo-2-chloro-1-methylbenzene (308 mg, 1.50 mmol), the reaction was carried out in the same manner as Example 23 to obtain the title compound 213 mg (yield 58%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08957069B2 |
| 出典データセット | uspto-grants-2015_02 |
| ORD ID | ord-c5a563e6f3904bdea15fdd2f3b1293e8 |
| 出典メモ | uspto-grants-2015_02 |