2-Methyl-2H-pyrazol-3-ylamine → 1-(1-methyl-1H-pyrazole-5-yl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

HRID 1850508ノート

反応式

HRID 1850508 の反応式
Cl[CH2:2][CH2:3][N:4]([CH2:19][CH2:20]Cl)[C:5]1[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[C:15]=1[CH3:16].[CH3:22][N:23]1[C:27]([NH2:28])=[CH:26][CH:25]=[N:24]1>>[CH3:22][N:23]1[C:27]([N:28]2[CH2:20][CH2:19][N:4]([C:5]3[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]4[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=4[C:15]=3[CH3:16])[CH2:3][CH2:2]2)=[CH:26][CH:25]=[N:24]1

参加物

3

反応物 2

HCID 1369272-Methyl-2H-pyrazol-3-ylamineHCID 66760837N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine

生成物 1

HCID 594850481-(1-methyl-1H-pyrazole-5-yl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine収率 4%

実験手順

By using N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine (660 mg, 2.0 mmol) synthesized in Reference Example 146 and 1-methyl-1H-pyrazole-5-amine (233 mg, 2.4 mmol), the reaction was carried out in the same manner as Example 117 to obtain 26 mg of the title compound as a colorless solid (yield 4%). Melting point was 126 to 128° C. (ethanol-water).

出典と根拠

ORDレコード
ord-57a879ad929349ab959a79570379b986
出典データセット
uspto-grants-2015_02
特許番号
US08957069B2

反応ノート

読み込み中…