tert-Butyl (1-isopropylpiperidin-4-yl)carbamate → 1-(Propan-2-yl)piperidin-4-amine

HRID 18506

反応式

HRID 18506 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]1)(C)(C)C>CO.Cl>[CH:14]([N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:16])[CH3:15]

参加物

4

反応物 1

HCID 20801240tert-Butyl (1-isopropylpiperidin-4-yl)carbamate

生成物 1

HCID 31633331-(Propan-2-yl)piperidin-4-amine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

To 4.8 g (1-Isopropyl-piperidin-4-yl)-carbamic acid tert-butyl ester in 15 mL methanol, 20 mL methanolic hydrochloric acid (8 M) were added and the mixture was stirred for 16 h. Removal of the solvent under reduced pressure, followed by removal of residual volatiles by twice coevaporating with toluene, gave the product. Yield: 5.42 g MS (ES+): m/e=143.

後処理

  1. customRemoval of the solvent under reduced pressure
  2. customfollowed by removal of residual volatiles
  3. customgave the product

出典と根拠

ORDレコード
ord-6fa2e1b0db5b4502a6fba40fd57bed62
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

読み込み中…