Hydroxylamine → HCID 178513430、化合物
反応式
[OH:1][CH2:2][CH2:3][C@@H:4]1[CH2:6][C@@H:5]1[CH:7]1[CH2:12][CH2:11][N:10]([C:13]#[N:14])[CH2:9][CH2:8]1.[NH2:15][OH:16]>C(O)C>[OH:16][NH:15][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([C@H:5]2[CH2:6][C@H:4]2[CH2:3][CH2:2][OH:1])[CH2:8][CH2:9]1)=[NH:14]参加物
4
反応条件
- 温度
- 65 °C
実験手順
4-((1R,2S)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carbonitrile (4.1 g, 21.10 mmol) was dissolved in Ethanol (60 ml) and hydroxylamine (5.17 ml, 84 mmol) (50% water solution) was added dropwise. The mixture was heated at 65° C. for 1 h. The mixture was evaporated to afford the desired product which was used for the next step without further purification. Rf was 0 @ 70% EtOAc in hexanes (blue spot on CAM stain)
後処理
- customThe mixture was evaporated
出典と根拠
- ORDレコード
- ord-6daab790a6a64dd1bb0556ab5b31f87a
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957062B2
反応ノート
読み込み中…