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Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Bromoacetyl bromide | HCID 61147 | — |
| 反応物 | 2-Amino-5-chloropyridine | HCID 66174 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide | HCID 3421110 | — |
反応手順
To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741341B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-31ec5a5ff49240e090abf794e19ea941 |
| 出典メモ | uspto-grants-2010_06 |