Sodium Methoxide → 5-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

HRID 1851200ノート

反応式

HRID 1851200 の反応式
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1.[CH3:18][O-:19].[Na+]>CO.ClCCl.O>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([O:19][CH3:18])[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1

参加物

6

反応物 2

HCID 10942334Sodium MethoxideHCID 594278075,7-Dichloro-6-phenylpyrazolo[1,5-a]pyrimidine

生成物 1

HCID 866306725-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

1.00 g 5,7-dichloro-6-phenylpyrazolo[1,5-a]pyrimidine (prepared as described above) were dissolved in 20 mL methanol and 20 mL dichlormethane. 1.2 g sodium methylate was added at 0° C. and stirred at room temperature for 2 h. The solution was diluted with water and dichloromethane. The organic phase was separated and the water phase was extracted with dichloromethane. The combined organic layers were dried over Na2SO4 and the solvent was evaporated. The crude product was used without further purification.

後処理

  1. customThe organic phase was separated
  2. extractionthe water phase was extracted with dichloromethane
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. customthe solvent was evaporated
  5. customThe crude product was used without further purification

出典と根拠

ORDレコード
ord-e36001ddfe90458f8527500d22ca2b29
出典データセット
uspto-grants-2015_02
特許番号
US08957064B2

反応ノート

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