Hydrochloric Acid → HCID 68753946、化合物
反応式
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]3)[NH:10][N:9]=2)[CH:5]=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH:15]1[CH2:16][CH:13]([C:11]2[NH:10][N:9]=[C:8]([C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=3)[N:12]=2)[CH2:14]1参加物
4
実験手順
11.6 g (36.8 mmol) tert-Butyl 3-[3-(6-methylpyridine-2-yl)-1H-1,2,4-triazole-5-yl]azetidine-1-carboxylate are dissolved in 150 mL dioxane. 27.6 mL HCl in dioxane (4M) are added dropwise and the reaction mixture is stirred over night at room temperature. The reaction mixture is evaporated to dryness yielding 13.1 g (76.6%) of the desired salt which is 60% pure and is used without further purification.
後処理
- customThe reaction mixture is evaporated to dryness
出典と根拠
- ORDレコード
- ord-62690b56809448f288d7c43f67ce7d2f
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957064B2
反応ノート
読み込み中…