2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178505975、化合物

HRID 1851256ノート

反応式

HRID 1851256 の反応式
[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 866306594-(3-Fluoro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

生成物 1

HCID 178505975HCID 178505975、化合物収率 57.6%

実験手順

This compound was prepared in analogy by reacting 90 mg (0.28 mmol) 4-(3-fluoro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzaldehyde with 93 mg (0.34 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 81 mg of the desired product were obtained.

後処理

  1. customThis compound was prepared in analogy
  2. waitAfter four and a half hours the reaction mixture was worked up
  3. custompurified in the usual way

出典と根拠

ORDレコード
ord-4b171b676b314596840d16651b3db474
出典データセット
uspto-grants-2015_02
特許番号
US08957064B2

反応ノート

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