2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178478263、化合物

HRID 1851257ノート

反応式

HRID 1851257 の反応式
[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 867030314-(3-Chloro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

生成物 1

HCID 178478263HCID 178478263、化合物収率 52%

実験手順

200 mg (0.6 mmol) 4-(3-chloro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde was reacted with 197 mg (0.72 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 162 mg of the desired product were obtained

後処理

  1. waitAfter four and a half hours the reaction mixture was worked up
  2. custompurified in the usual way

出典と根拠

ORDレコード
ord-7b93f7db50ed499ca6584dffa99ba29b
出典データセット
uspto-grants-2015_02
特許番号
US08957064B2

反応ノート

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