Ethanol → HCID 136060800、化合物

HRID 1851517ノート

反応式

HRID 1851517 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19](=[S:21])[NH2:20])=[CH:15]2)(=[O:8])=[O:7].Br[CH2:23][C:24](=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26].C(O)C.CN(C)C(=O)C>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]1[S:21][CH:23]=[C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=1)=[CH:15]2)(=[O:7])=[O:8]

参加物

6

反応物 4

HCID 702EthanolHCID 31374DimethylacetamideHCID 66144Ethyl bromopyruvateHCID 57901763HCID 57901763、化合物

生成物 1

HCID 136060800HCID 136060800、化合物収率 36.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide (0.30 g), ethyl bromopyruvate (0.21 g), ethanol (2 mL) and N,N-dimethylacetamide (2 mL) was stirred at 80° C. for 4 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried. The obtained crystals were recrystallized from ethyl acetate to give the title compound (0.14 g, yield 36%) as pale-yellow crystals. melting point 240-241° C.

後処理

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried
  4. customThe obtained crystals were recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-d5675cef08c6442fa90391e097f69713
出典データセット
uspto-grants-2015_02
特許番号
US08957070B2

反応ノート

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