Ethanol → Carfentrazone-ethyl

HRID 1851698ノート

反応式

HRID 1851698 の反応式
[Cl:1][CH:2]([CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[C:17](=[O:18])[N:16]([CH:19]([F:21])[F:20])[C:15]([CH3:22])=[N:14]2)[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])[C:3]([OH:5])=[O:4].[CH2:25](O)[CH3:26]>C1C=CC=CC=1>[CH3:25][CH2:26][O:4][C:3]([CH:2]([Cl:1])[CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[N:14]=[C:15]([CH3:22])[N:16]([CH:19]([F:20])[F:21])[C:17]2=[O:18])[C:10]([F:23])=[CH:9][C:8]=1[Cl:24])=[O:5]

参加物

4

反応物 2

HCID 702EthanolHCID 443229Carfentrazone

生成物 1

HCID 86222Carfentrazone-ethyl

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

adding 1 mol of the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl]-4-fluorophenyl}propionic acid of the step (1), 4˜10 mol of ethanol and 0.03˜0.2 mol of an acid catalyst into 6˜12 mol of the solvent of benzene class; refluxing the reaction mixture until an esterification is completed; washing successively with water, with aqueous alkali base and then with water; and removing the solvent totally from the organic layer, to give a product carfentrazone-ethyl.

後処理

  1. temperaturerefluxing the reaction mixture until an esterification
  2. washwashing successively with water, with aqueous alkali base
  3. customand removing the solvent totally from the organic layer

出典と根拠

ORDレコード
ord-966f7c3946f24150af6c7d28d633701b
出典データセット
uspto-grants-2015_02
特許番号
US08957220B2

反応ノート

読み込み中…