Hydrochloric Acid → (S)-1-(4-(tert-butyl)phenyl)ethanaminium chloride
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C@@H:11]([NH:13][S@@](C(C)(C)C)=O)[CH3:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:20]>CO>[Cl-:20].[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([NH3+:13])[CH3:12])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
To a solution of (R)—N—((S)-1-(4-(tert-butyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (977 mg) in MeOH (1.75 mL) was added conc. HCl (1.75 mL). The reaction was aged at room temperature monitoring disappearance of starting material by analytical reverse-phase HPLC. When the starting material was consumed, the reaction was concentrated in vacuo. The crude residue was resuspended in MeOH (1 mL) and crashed out of solution by the addition of Et2O. Filtration afforded the title compound as a colorless solid (559 mg). ESI-MS (m/z): 161 [M+H—NH3]+, 338 [2M+H—NH3]+