Cesium fluoride → HCID 71742701、化合物
反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:13][CH3:14])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[F-:15].[Cs+]>CS(C)=O.CCOC(C)=O>[F:15][C:2]1[C:11]2[C:6](=[C:7]([O:13][CH3:14])[CH:8]=[C:9]([F:12])[CH:10]=2)[CH:5]=[CH:4][N:3]=1参加物
5
反応条件
- 温度
- 140 °C
実験手順
To a solution of 1-chloro-7-fluoro-5-methoxyisoquinoline (350 mg, 1.654 mmol) in DMSO (3 mL), was added CsF (502 mg, 3.31 mmol) and the mixture was heated to 140° C. for 4 h. The reaction was diluted with EtOAc and washed with water, and brine. The organic phase was collected, dried over sodium sulfate, and concentrated under vacuum to give 1,7-difluoro-5-methoxyisoquinoline (340 mg, 105% yield) which was not purified further. MS m/z 196.1 (M++1).
後処理
- washwashed with water, and brine
- customThe organic phase was collected
- dry with materialdried over sodium sulfate
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-c10dbc402c364ccd93f8463e129ce2f9
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957203B2
反応ノート
読み込み中…