Potassium tert-butoxide → tert-butyl ((2R,6S,7R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-1-yl)oxy)-7,9-dimethyl-14a-(((1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl)carbamate

反応式

[OH:1][C@H:2]1[CH2:42][N:5]2[C:6](=[O:41])[C@@H:7]([NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])[C@H:8]([CH3:32])[CH2:9][CH:10]([CH3:31])[CH2:11][CH2:12][CH:13]=[CH:14][C@@H:15]3[CH2:20][C@@:16]3([C:21](=[O:30])[NH:22][S:23]([C:26]3([CH3:29])[CH2:28][CH2:27]3)(=[O:25])=[O:24])[NH:17][C:18](=[O:19])[C@@H:4]2[CH2:3]1.Cl[C:44]1[C:53]2[C:48](=[CH:49][C:50]([O:54][CH3:55])=[CH:51][CH:52]=2)[CH:47]=[C:46]([N:56]([CH3:58])[CH3:57])[N:45]=1.CC(C)([O-])C.[K+]>CS(C)=O>[CH3:57][N:56]([CH3:58])[C:46]1[N:45]=[C:44]([O:1][C@H:2]2[CH2:42][N:5]3[C:6](=[O:41])[C@@H:7]([NH:33][C:34](=[O:40])[O:35][C:36]([CH3:39])([CH3:38])[CH3:37])[C@H:8]([CH3:32])[CH2:9][CH:10]([CH3:31])[CH2:11][CH2:12][CH:13]=[CH:14][C@@H:15]4[CH2:20][C@@:16]4([C:21](=[O:30])[NH:22][S:23]([C:26]4([CH3:29])[CH2:28][CH2:27]4)(=[O:24])=[O:25])[NH:17][C:18](=[O:19])[C@@H:4]3[CH2:3]2)[C:53]2[C:48]([CH:47]=1)=[CH:49][C:50]([O:54][CH3:55])=[CH:51][CH:52]=2