Dimethylamine → HCID 70978361、化合物

HRID 1852271ノート

反応式

HRID 1852271 の反応式
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH3:15][N:16]([CH3:17])[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5](=[O:14])[NH:4][CH:3]=1

参加物

3

反応物 2

HCID 674DimethylamineHCID 579564624-Bromo-6-methoxyisoquinolin-1(2H)-one

生成物 1

HCID 70978361HCID 70978361、化合物収率 116.2%

実験手順

A solution of 4-bromo-6-methoxyisoquinolin-1(2H)-one (1 g, 3.94 mmol) in dimethylamine (5 ml, 39.5 mmol) was heated to 105° C. for 48 h. After cooling, the reaction mixture was concentrated under reduced pressure to get 4-(Dimethylamino)-6-methoxyisoquinolin-1(2H)-one (0.8 g, 4.58 mmol, 85% yield). MS: MS m/z 219.20 (M++1).

後処理

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-644c4ba85e754b3b8f64bad0b14b3bde
出典データセット
uspto-grants-2015_02
特許番号
US08957203B2

反応ノート

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