Formamidine → HCID 178487763、化合物
反応式
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13](N)=[NH:14]>O>[CH3:12][O:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4]([OH:5])=[N:14][CH:13]=[N:1]2)=[CH:7][CH:8]=1参加物
4
反応条件
- 温度
- 125 °C
実験手順
To a solution of 2-amino-4-methoxy benzoic acid (8.6 g, 51.4 mmol) in 2-dimethoxy ethane (100 ml) was added formamidine (10.71 g, 103 mmol). The reaction mass was heated to 125° C. 18 h. The reaction mass was diluted with cold water. The precipitated solid was filtered, washed with water to get crude compound (6.92 g, 74.8%) as pale yellow solid. 1H NMR (400 MHz, DMSO): δ ppm 12.10 (br, s, 1H), 8.06 (s, 1H), 8.03-8.01 (d, J=8 Hz, 1H), 7.11-7.09 (m, 2H), 3.89 (s, 3H);
後処理
- custom18 h
- filtrationThe precipitated solid was filtered
- washwashed with water
出典と根拠
- ORDレコード
- ord-e60692753d6c4e2fb25f772f16ce0df7
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957203B2
反応ノート
読み込み中…