Water → 4-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene

HRID 1852365ノート

反応式

HRID 1852365 の反応式
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N+:11]([O-:13])=[O:12].[CH3:14][C:15]1[CH:16]=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[C:19]([OH:21])[CH:20]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:14][C:15]1[CH:16]=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[C:19]([O:21][CH2:2][CH2:3][O:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N+:11]([O-:13])=[O:12])[CH:20]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 127886-Nitro-m-cresolHCID 43624871-(2-chloroethoxy)-2-nitrobenzene

生成物 1

HCID 27630554-Methyl-1-nitro-2-[2-(2-nitrophenoxy)ethoxy]benzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

1-(2-Chloro-ethoxy)-2-nitro-benzene (116 g) and 5-methyl-2-nitro-phenol (88 g) were dissolved in 500 ml DMF and was stirred for 4 h at 90-110° C. after careful addition of 160 g potassium carbonate. The reaction mixture was poured in a mixture of crushed ice and water (8 l) which was vigorously stirred. The residue was filtered off, washed several times with water and dried. The crude product was suspended in methanol and the pale yellow residue was again filtered off, washed with methanol and dried. Yield: 150-165 g.

後処理

  1. stirringwas vigorously stirred
  2. filtrationThe residue was filtered off
  3. washwashed several times with water
  4. customdried
  5. filtrationthe pale yellow residue was again filtered off
  6. washwashed with methanol
  7. customdried

出典と根拠

ORDレコード
ord-22c6d06fd49b4326b2ec6360d3ecb503
出典データセット
uspto-grants-2015_02
特許番号
US08962338B2

反応ノート

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