Triethylamine → 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

HRID 18527

反応式

HRID 18527 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]([OH:12])=O.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][C:21]2=[O:26])=[CH:16][CH:15]=1.C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.CCN(CC)CC>C(Cl)Cl.O>[O:26]=[C:21]1[CH2:22][O:23][CH2:24][CH2:25][N:20]1[C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:10]([C:2]2[NH:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)=[O:12])=[CH:19][CH:18]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 2332402-Benzimidazolecarboxylic acidHCID 111948544-(4-Aminophenyl)morpholin-3-one

生成物 1

HCID 860098191H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 100 mg 1H-Benzoimidazole-2-carboxylic acid and 118 mg 4-(4-Amino-phenyl)-morpholin-3-one in 2 mL DCM, 157 mg BOP-Cl and 0.3 mL NEt3 were added and the mixture was stirred for 16 h at RT. Then, after the reaction mixture was diluted with 20 mL water, the precipitated product was collected by filtration. The crude product was subjected to the next reaction step without further purification. Yield: 122 mg.

後処理

  1. filtrationthe precipitated product was collected by filtration
  2. customThe crude product was subjected to the next reaction step without further purification

出典と根拠

ORDレコード
ord-9c72ab4d86a7485eb49a9fb83d92fa99
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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