化工社化工社 化学情報印刷レポート · 研究参考用
Toluene → Benzimidazole, 2-trichloromethyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | O-Phenylenediamine | HCID 7243 | — |
| 反応物 | Methyl 2,2,2-trichloroacetimidate | HCID 100479 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Benzimidazole, 2-trichloromethyl- | HCID 77133 | — |
反応手順
To a solution of 10 g Benzene-1,2-diamine in 250 mL acetic acid, 22.8 g 2,2,2-Trichloro-acetimidic acid methyl ester were added drop wise at RT. After 2 h 500 mL toluene were added and the solvents were removed under reduced pressure. The residue was codestilled additional two times with toluene. After drying under reduced pressure the product was pure enough for the next reaction step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741341B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0afa7b3ef23347f6a27ba72298be89b9 |
| 出典メモ | uspto-grants-2010_06 |