3-Amino-2-phenyl-4(3H)-quinazolinone → 2-(1-adamantyl)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide

関与物質

反応手順

3-Amino-2-phenyl-4(3H)-quinazolinone and 1-adamantaneacetyl chloride were reacted as described in Example 5 to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.11-1.15 (m, 3H), 1.33-1.44 (m, 6H), 1.53-1.57 (m, 3H), 1.72-1.77 (m, 3H), 1.79-1.92 (m, 2H), 7.43-7.50 (m, 3H), 7.58-7.64 (m, 3H), 7.73-7.76 (m, 1H), 7.88-7.64 (m, 1H), 8.18-8.21 (m, 1H), 10.96 (s, 1H) ppm; MS (DCI/NH3) m/z 414 (M+H)+; Elemental Analysis: Calculated for C26H27N3O2.1.15H2O: C, 71.92; H, 6.80; N, 9.68. Found: C, 71.93; H, 6.79; N, 9.77.

情報源と証拠